Please email the information below along with a FASTA file of candidate HAdV genome nucleotide sequence to Dr. James Brister (jamesbr@ncbi.nlm.nih.gov) and Dr. Olga Blinkova (olga.blinkova@nih.gov) with the subject line “Human Adenovirus Working Group.”
All type submissions will be forwarded to the Working Group from NCBI without any author identifying information to insure anonymity of submitter.
- Your contact information.
- Designation of strain.
For example, the universal name for HAdV-D53 is
Adenovirus D human/DEU/IAI-1/2005/53[P37H22F8]
Where DEU is the country code and country of isolation
and IAI-1 is the lab name or unique identifier from the contributer
and 2005 is the year of isolation
and 53[P37H22F8] is the proposed type number with, in brackets, the penton base it is closest to and the hexon L1/L2 it is closest to and the fiber knob it is closest to.
- Date and place of isolation.
- Complete genome and analysis?
- Evidence- why do you consider this a novel type?
a) Is it based on phylogenomics? How do the phylogenetic trees for the whole genome, penton base, hexon loop 1, hexon constant and fiber knob compare?
For example, the gene map and phylogenomics data presented in M.P. Walsh, et al. (09). PLoS ONE 4:e5635 demonstrated that HAdV-D53 was a recombinant adenovirus which contained genes from different adenoviruses.
b) Is it based on sequence metrics?
Please submit %GC, %genome difference from next closest adenovirus.
For example, the data presented in M. S. Jones, et al. (07). J. Virol. 81:5878 demonstrated that HAdV-G52 was exceptionally distant from viruses in species HAdV-A and HAdV-F, which were its closest phylogenetic neighbors.
c) Are there genome change and significant biological and/or pathogenic changes?
For example, the gene map and phylogenomics data presented in M. P. Walsh, et al. (10). J. Clin. Microbiol. 48:991 demonstrated that HAdV-B55, which has the hexon loop 1 and serum neutralization epitope of HAdV-B11 (a renal pathogen), behaves like a respiratory pathogen with a fiber knob and hemagglutination inhibition epitope of HAdV-B14.
- PLEASE SUBMIT SUPPORTING DATA, INCLUDING FIGURES (IMPORTANT), FOR OUR EVALUATION.